A series of nine 1-(4-aryl-2-thiazolyl)-3,5-diaryl and six of 1-(4-aryl-2-oxazolyl)-3,5-diaryl-2- pyrazolin derivatives were prepared by reacting 3,5-diaryl-1-thiocarbamoyl-/or3,5-diaryl-1- carbamoyl-D2-pyrazolines with substituted phenacyl bromide in ethanol. The structures of the synthesized derivatives were confirmed by IR, 1H-NMR, 13C-NMR as well as EIMS spectral data. Some of these derivatives were screened for their antimicrobial activity against Gram-positive, Gram- negative and pathogenic fungi, and showed a significant activity.