Ethyl 4-piperidone reacts with different amines in presence of toluene as a solvent and water is removed and Schiff base is formed. Then this Schiff base undergoes reduction and reduced product of Schiff base is obtained. Then it is undergoes for benzoylation, After benzoylation It reacts with two different azides and forms again Schiff base for both azides which further undergoes for clemensen reduction. The reduction product of both azides reacts with ethyl acetoacetate and undergoes cyclization and formed to get the desired cyclized product. product for antifungal screening by zone of inhibition study respect to some gram positive and gram negative microbes reference standard antibiotics. The satisfactory result has been found in the antifungal screening.