Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 4

Synthesis and antibacterial evaluation of some hydrazones of flavanoid derivatives


In an effort to synthesize potent anti-bacterial agents, few hydrazones of Flavanol derivatives have been synthesized and screened for in vitro anti-bacterial activity against 25 strains of Gram –ve and Gram +ve pathogenic bacteria. The chemical structures of compounds were established by IR, NMR spectra and elemental analysis. The synthesized compounds have shown inhibitory effect (MIC< 392 μg/ml) against few pathogenic bacterial strains and also posses activity against Methicillin-resistant Staphylococcus aureus strain because of presence of carbonyl region and hydroxyl group