The present study was carried out to investigated the duration exposure time and toxicity on survival effects for two freshwater fish Common C. carpio an Liza abu to different concentration of Chlorpyrifos o-phenylphenol, chlorothalonil, metalaxyl pesticide (2,4,6,8 and 10 mg/L) for acute exposure (24,48. 72 and 96 hour) and (0.1,0.3,0.5,0.7,0.9 and 1.0 mg/L) to sub lethal exposure for period (5,10 and 15 days), during 96 h and LC50 values at 96 h (3.54 mg/) for C. carpio and (2.15 mg/L) for Liza abu with 95% confidence limit, these differences in the LC50 value between two fish Liza abu more sensitive than C. carpio, whereas in Sub-lethal effects LT50 values at 96 h are indicated (21.87 h and 17.78 h) respectively for two fishes, and noticed the behavioral changes fish appeared irregular, erratic and darting movements with imbalanced swimming activity and attempt to jump out of the toxic medium were observed increase the secretion of mucus and accumulated on the fish body to open the operculum with rapid movements to increase the speed of breathing.