Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2019 Vol: 11 Issue: 1

Study the Effect of Prunus amygdalus Dry Fruit Ethanolic Extract on Cognitive Function in High Fat Diet Induced Obesity Rats


Currently, the cognitive function of high fat diet- induced obesity rats was investigated in the presence of Prunus amygdalus dry fruit ethanol extract. Obesity rats were prepared by feeding 30 days of high fat diet, confirmed obesity rats were divided into groups and Prunus amygdalu was then treated. Obesity rats were prepared by feeding of high fat diet for 30 days, confirmed obesity rats were divided in into groups, and then treated Prunus amygdalus fruit ethanolic extract (100 and 200 mg/Kg B.wt.) for 30 days. Cognitive function was assessed at the time of 25th, 27th, 30th, 42th, 44th and 45th day and lipid profile and body weight was determined on 30th and 45th day, antioxidant activity was estimated at the end of 45th day, results were interpretated using graph pad prism 5. Results were concluded that rats significantly increased body weight, cognitive impairment and increased total cholesterol, triglycerides, LDL and decreased HDL in high fat diet rats, that was ameliorated by treatment of Prunus amygdalus fruit ethanolic extract. Conclusion that the Prunus amygdalus fruit treatment enhanced cognitive function as well as maintained balanced lipid profile in obesity rats.