This paper discusses some problems existing in the interdisciplinary electronic technology experimental teaching of some common local undergraduate colleges, explores teaching reform aiming at teaching content, teaching methods and evaluation mechanisms, and summarizes some feasible countermeasures. By taking the designing and guiding process of experimental project "Manufacturing and Debugging of DC Stabilized Power Supply" as an example, this paper specifically illustrates how to develop and implement experimental teaching method of project leading mode by applying simulation technology, to improve the cultivation quality of technical talents, and improve students' thinking innovative spirit and practical ability.