The government sampling inspection pass rate of Distribution Transformers (DTs) is less than 75% in China, which causes serious impact to the product quality and brings serious security risks. In order to improve the whole quality of DTs, it has important significance to study quality control method. The main quality defects and reasons of the DTs are introduced. The game theory of sampling inspection is analyzed. The method of establishing quality information system of DTs based on life cycle theory is proposed, which includes production, installation, operation and maintenance process. The DT’s quality control method based on life cycle information is study on. The effect of the method is verified by the large power transformer sampling example.