Healthy operation of urban water system contributes to urban sustainable development. The study on the healthy operation of reuse of reclaimed water in this system is the current priority. Tianjin is located in the eastern part of North China. Lack of fresh water resources has been a hindrance to its economic and social development. To remove this bottleneck, Tianjin initiated a number of projects to reuse reclaimed water for agricultural irrigation, groundwater recharge, industry, landscapes and recreation areas. If handled improperly, the reuse would pose a threat to human health. In this study, health risk assessment (HRA) model is adopted to monitor the reclaimed water quality at three observation stations in Tianjin, risk factors are obtained by horizontal and vertical contrast, and rectification measures are proposed.