Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2018 Vol: 10 Issue: 8

Study of Prescription Pattern of Oral Hypoglycemic Agents in Relation to Gfr Appropriateness in Diabetes Mellitus with Nephropathy

Abstract

Aim: The decline in the renal function impairs the clearance and metabolism of the anti-diabetic agents and insulin, resulting in the frequent requirement of the prescription reassessment. Objective:The objective is to sort out the inappropriateness in the prescription pattern of oral hypoglycemic agents in diabetes mellitus with nephropathy. Method:The prescriptions were randomly selected for the study, after they fulfilled the necessary inclusion, exclusion criteria. After obtaining the informed consent form, the socio demographic data, details of anti-diabetic therapy, required laboratory investigations (serum creatinine, BUN, BUN:Se.cr ratio, CUE, HbA1C), hypoglycemic episodes (if any) are recorded. Another required parameter GFR is calculated using CKD-EPI equation. Fischer exact test is used to test the significance of hypoglycemic episodes among CKD 1-2 and CKD 3-5. Results:Metformin+Glimepiride combination is the most commonly prescribed medication (34.6%), followed by metformin alone (23.07%). The drugs which are found to be least prescribed are Glipizide (1.92%), Sitagliptin (1.92%), Pioglitazone (0.96%). Inappropriately prescribed drug which is highly responsible for hypoglycemic episodes is Metformin+Glimepiride (22.22%). Conclusion:Biguanides and sulphonylureas have been found to dominate the prescription pattern of DM-II, despite of the presence of the comorbidity such as nephropathy.