Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2014 Vol: 6 Issue: 6

Study of novel pyrrolidine compounds


4-(1,3-dioxoisoindolin-2-yl)benzohydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding N'-arylidene-4-(1,3-dioxoisoindolin-2-yl)benzohydrazide (2a-e) in good yields. Compounds (2a-e) on cyclo condensation with Succinic anhydride yields 1-(4-(1,3-dioxoisoindolin-2-yl)benzamido)-5-oxo-2- arylpyrrolidine -3-carboxylic acid (3a-e). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities

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