Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 9

Study of antioxidant and anti-inflammatory activities of methanol extract ofDesmodium gyrans (DC)

Abstract

Desmodium gyrans (DG) is a medicinal plant used for a number of properties in traditional medicine. GC-MS analysis and study on antioxidant and anti-inflammatory activities of DG were done using 70% methanol extract of the whole plant. The IC50 values of DG for scavenging superoxide, DPPH, Hydroxyl and ABTS radicals and inhibiting lipid peroxidation were found to be 12.6, 4.0, 13.5, and 1.95 and 74.0 μg/ml respectively. Both acute and chronic anti-inflammatory studies were performed in hind paw of Balb/c mice. The percentage inhibitions were found to be 13.02 and 17.39 in acute study and 13.9 and 31.71in chronic anti-inflammatory experiments. The results showed that 70% methanol extract of DG has excellent antioxidant activity and anti-inflammatory activity, especially during chronic inflammation. GC-MS analysis showed the presence of phytochemicals active in inhibiting inflammation thus validating the anti-inflammatory activity of Desmodium gyrans extract