Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2013 Vol: 5 Issue: 5

Study of anthelmintic properties of 1-Nicotinoyl-4-aryl-3-methyl 3a,4-dihydropyrazolo[3,4c] pyrazoles and their inclusion complexes with ?²-cyclodextrin

Abstract

Five different fused pyrazoles with nicotinoyl moiety and their inclusion complexes with β-cyclodextrin have been prepared. The formation of compounds and their inclusion complexes have been ascertained from the determination of melting point, elemental analysis and spectral properties. Finally, the compounds and their inclusion complexes have been screened for anthelmintic activities. It is found that there happens a significant increase in anthelmintic activities due to the formation of inclusion complexes.