A new type of amine based anti-collapse drilling fluid is developed with strong inhibition for solving hydration swelling, hole shrinkage, and serious mud-making problems while meeting with mud shale formation in horizontal drilling in Sulige gas field. Performance evaluation results show that the good compatibility between organic amine inhibitors and drilling fluid is conducive to maintain the high temperature stability of the drilling fluid, and improve the drilling fluid filtration performance; the amine based drilling fluid, with good inhibition, strong pollution resistance, temperature resistance, resistance to calcium, and small damage for gas reservoirs, belongs to the clean water based drilling fluid system. Field application results show that the drilling fluid system is beneficial to improve wall stability of mud shale formation in Sulige gas field, solve the problem of hard control of drilling fluid rheological property in mud shale formation, and to achieve the requirements of protecting reservoir. This amine based drilling fluid can satisfy the need of drilling in Sulige gas field.