Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2013 Vol: 5 Issue: 10

Studies on synthesis, characterization, antifungal and antibacterial activities of organosilicon derivatives

Abstract

Schiff base complexes have an important and popular area of research due to their simple synthesis, versality and diverse range of applications.[1] The Schiff bases play a significant role in the area of coordination chemistry. The study of a range of coordination compounds is linked to the coordination of metals with the Schiff base ligands. The schiff bases are widely used ligands to synthesize their metal complexes due to their facile synthesis, significant and good solubility in common organic solvents. Thus, they have played a important applicable role in research and development of coordination chemistry as they readily form stable metal complexes in different oxidation states[2]. The schiff base complexes of main group elements containing ligands such as semicarbazones and thiosemicarbazones have remained a topic of significant current research interest[3]. This is mainly because of biological applications not only of ligands but also of compounds derived from them. Semi- and thiosemicarbazones can act as neutral or charged ligands. They can show tautomerism and can exist in keto/thione or enol/thiol form. semicarbazones and thiosemicarbazones have also attracted attention due to their biological activities. These compounds present a wide variety of biological activities such as antitumoral[4,6] fungicidal[7,8] bactericidal[9] and antiviral. It is known that some drugs have increased activity when administered in the form of the metal complexes[10] and a number of metal chelates inhibit tumor growth.[11] In the treatment of cancer, the active species is not the semicarbazones or thiosemicarbazones but their metal chelates.[11,12] The rapid rise in the industrial, agricultural, biological, and medical applications of organosilicon(IV) compounds during the last few decades have led to their accumulation in the environment and in biological systems. Organosilicon compounds of sulfur containing ligands have attracted much attention recently due to their biological importance. The sulfur containing ligands are well known for their anticarcinogenic, antibacterial, tuberculostatic, antifungal and acaricidal effect. It has been reported that the activity of sulfur-containing ligands increases on complexation