Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2010 Vol: 2 Issue: 2

Studies on inclusion complexes of substituted indole derivatives with activating and deactivating group

Abstract

Indole and its analogous are very good pharmacophores exhibiting wide spectrum of fungicidial, bactercidial and tuberculostic activities.These have poor solubility in polar medium which may be a limiting factor reducing their bio-accessibility. The solubility of these compounds in aqueous medium( polar medium) can be enhanced by forming inclusion complexes with a nontoxic oligosaccharide, namely β-cyclodextrin. In this paper an attempt has been made to synthesise some [arylidenamino]-1,3,4-thiadiazino[6,5b]indoles with activating(Hydroxy)and deactivating(Nitro)groups in their purest form and then to prepare their respective inclusion complexes with β-cyclodextrin. The formation of compounds and their inclusion complexes have been ascertained from elemental analysis and study of spectral characterstics. Thermodynamics properties of the inclusion complexes are also studied to know whether the formation of inclusion complex is thermodynamically stable or not. In addition,the study of thermodynamic properties also reveal the type of interaction existing in between the host β-cyclodextrin and the compound concerned.