Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 3

Studies on inclusion complexes of substituted indole derivatives with activating and deactivating group

Abstract

Indole and its analogous are very good pharmacophor es exhibiting wide spectrum of fungicidial, bactercidial and tuberculostic activities.These hav e poor solubility in polar medium which may be a limiting factor reducing their bio-accessibili ty. The solubility of these compounds in aqueous medium( polar medium) can be enhanced by fo rming inclusion complexes with a non- toxic oligosaccharide, namely β -cyclodextrin. In this paper an attempt has been ma de to synthesise some [arylidenamino]-1,3,4-thiadiazino[6 ,5b]indoles with activating(Hydroxy)and deactivating(Nitro)groups in their purest form and then to prepare their respective inclusion complexes with β -cyclodextrin. The formation of compounds and their inclusion complexes have been ascertained from elemental analysis and study of spectral characterstics. Thermodynamics properties of the inclusion complexes are also stud ied to know whether the formation of inclusion complex is thermodynamically stable or no t. In addition,the study of thermodynamic properties also reveal the type of interaction exis ting in between the host β -cyclodextrin and the compound concerned.