Traditional and folklore medicines play an important role in health services around the globe. About three quarters of the world population relies on plants and plant products for health care. The plant Desmodium gangeticum has been used in folklore medicine in the treatment of various ailments. Many of the Ayurvedic formulations contain this medicinal plant and is considered as Master of Medicinal Plant in Ayurveda due to its wide use in formulations. In this detailed review article called Studies on Desmodium gangeticum, the Botany, Chemistry and Biological activities of the above mentioned plant is presented.