Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2016 Vol: 8 Issue: 10

Structure Elucidation of Anthraquinon Derivate from Cassia Alata Linn and Antioxidant Activity

Abstract

Cassia alata Linnis an Indonesian tropical plant that are well spread in tropical regions such as in the countries of Asia, America and Africa. This plant has traditionally been used as an anthelmintic, thrush. laxative, anti-parasitic, herpes, syphilis, scabies and other skin diseases. The objective of this reearch was to isolate the anthraquinone compound from the leaves of the plant. Extraction was done by soxhletation method, while purification was done by vacuum liquid chromatography with silica gel stationary phase and gradually eluted using Step Gradient Polarity (SGP) method by using the solvent n-hexane, ethyl acetate and methanol. Structure elucidation done by ultraviolet, infrared and 1H-NMR spectroscopy. Compound was isolated from ethyl acetate fraction as an orange powder as much as 8 mg. The isolated compound is anthraquinone derivate. Testing the antioxidant activity of the ethyl acetate fraction shown IC50 = 310 μg/ mL and classified as active antioxidants.