Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 1

Stability study of O/W emulsions using zeta potential

Abstract

Emulsions are widely used as medicinal and cosmetic delivery systems on account of general observations that emulsified materials normally pos sess the properties being exhibited by its bulk components. In order to widen scope of application of the conclusions drawn, o/w emulsions covering almost all routes of administration were c onsidered for the study. These included parenteral emulsion, oral Emulsion and topical emul sion. Zeta potential including zeta deviation and peak position, and effective particle size of t he emulsions including Z-average diameter, poly dispersity index and peak position were studie d using a Zeta sizer (Malvern instrument). Employing Laser Doppler Electrophoresis and dynamic light scattering technique, Zeta potential and particle size distribution of the droplet as a function of time can be determined, which was done in this paper. Zeta potential is used to study the chemistry involved in determining whether or not an emulsion will remain stable in the enviro nment where it will be used. Hence it is very much essential. The stability of all diluted emulsi ons (1% v/v) of samples in milli-Q water was studied. The parameters Zeta potential, particle si ze and pH were measured at 1, 2, 3, 6, 8, 10, 12, 15, 20, 30, 45, 60, 75, 90 days after dilution of the emulsions by mechanical mixing. On the stability study of all these parameters it was foun d that topical emulsion were most stable followed by oral and parenteral