Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 9

Stability Indicating Reverse phase Liquid chromatographic Method for the Determination of Metoprolol succinate in Pharmaceutical Dosage Forms

Abstract

This paper describes the development and validation of simple, Robust, Rugged and stability indicating liquid chromatographic analytical method for the Assay of Metoprolol succinate in Pharmaceutical Dosage forms. The method employs a Waters X-Terra RP 18(150mm X 4.6 mm, 5 μm particle size) column with UV detection at 240 nm. Method was designed to extract the drug substance Metoprolol succinate in any type of matrix formulations available in the market. This method can be used for Quality control assay of Metoprolol in finished dosage forms and for stability studies as the method separates all impurities and degradation products from Metoprolol.