Simple, precise and economical spectrophotometric methods have been developed for the simultaneous estimation of Flupentixol dihydrochloride and Melitracen hydrochloride in combined tablet dosage form. The first method is based on the use of simultaneous equation, the second method is based on the simultaneous equation using AUC of the two drugs, the third method is based on the use of absorbance ratio method and the fourth one is based on first order derivative method. Both the drugs obey the Beer’s law in the concentration ranges employed for these methods. The methods were validated by following the analytical performance parameters suggested by the International Conference on Harmonization. All validation parameters were within the acceptable range. The developed methods were successfully applied to estimate the amount of Flupentixol dihydrochloride and Melitracen hydrochloride in combined tablet dosage forms.