Simple, precise and economical spectrophotometric m ethods have been developed for the simultaneous estimation of Flupentixol dihydrochlor ide and Melitracen hydrochloride in combined tablet dosage form. The first method is ba sed on the use of simultaneous equation, the second method is based on the simultaneous equation using AUC of the two drugs, the third method is based on the use of absorbance ratio meth od and the fourth one is based on first order derivative method. Both the drugs obey the Beer’s l aw in the concentration ranges employed for these methods. The methods were validated by follow ing the analytical performance parameters suggested by the International Conference on Harmon ization. All validation parameters were within the acceptable range. The developed methods were successfully applied to estimate the amount of Flupentixol dihydrochloride and Melitrace n hydrochloride in combined tablet dosage forms