Simple and precise UV- spectrophotometric methods, second order derivative have been developed and validated for the estimation of azelnidipine in bulk drug and its tablet formulation. The standard and sample solutions of azelnidipine were prepared in methanol. Azelnidipine was estimated at 233.8 nm for the second order derivative UV-spectrophotometric method. Beer’s law was obeyed in the concentration range of 1 to 20 μg / ml with coefficient of correlation value 0.9993. The method was tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation, which was 0.5476 % for the above method. The proposed method was successfully applied for the determination of azelnidipine in pharmaceutical formulation. Results of the analysis were validated statistically and were found to be satisfactory. The proposed methods are simple, easy to apply, low-cost and require relatively inexpensive instruments.