Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2016 Vol: 8 Issue: 6

Spectrophotometric and chromatographic methods for estimation of Pantoprazole in combined dosage forms

Abstract

Pantoprazole is a Proton Pump Inhibitors (PPI’S) used in various commercial pharmaceutical formulations for the treatment of acid related gastrointestinal disorders such as bleeding peptic ulcer, for prophylaxis of acute stress ulcers, short term treatment of erosions & ulceration of the esophagus caused by gastro esophageal reflux disease and also used in the treatment of ulcer induced by Non-Steroidal Anti-Inflammatory Drugs. The various commercial pharmaceutical formulations of Pantoprazole in combination with other drugs such as, Diclofenac, Domperidone, Ondansetron, Cinitapride, Mosapride, Rabeprazole, Esompeprazole, Itopride, Levosulpride, Itopride hydrochloride, Ketoprofen, Valsartan, Benzimidazole sulfoxides are available in pharmaceutical market. In order to meet the standards of pharmacopoeial limits of the drug Pantoprazole in various pharmaceutical dosage forms many analytical methods have been developed and validated for the routine quality control. Keeping this in view various analytical tools developed for the analysis of Pantoprazole in combined dosage forms were reviewed briefly in the present study. The methods adopted were UV Spectrophotometric and High Performance Liquid Chromatographic (HPLC).