Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 6

Some physical characteristics of artemether and piroxicam solid lipid microparticles prepared with dika fat


Dika fat was applied in the formulation of artemether and piroxicam solid lipid microparticles. Hot homogenization method was used in the preparation of the microparticles with varying labrasol® surfactant concentration (0.5%, 1.0% and 1.5%w/w) and dika fat/ phospholipon® 90G ratios (1:0, 4:1 and 9:1). The microparticles were evaluated for particle size and drug encapsulation efficiency (EE%) while the pH of the unloaded microparticle dispersions was examined. Optimum particle sizes were observed at 1.5%w/w labrasol level and pH of the dispersions were slightly acidic. Drug encapsulation or entrapment efficiency of the microparticles decreased with the addition of phospholipon® 90G. Artemether and piroxicam can be loaded in dika fat based solid lipid microparticles.

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