Molar refraction (RM) and polarizability (a) of binary 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride hydrate drug in different solvents like water, methanol, ethanol and dimethyl sulfoxide were computed from experimental density (r) and refractive index (nD) data at 300C. Enhancement in overall polarizability of drug solution with relative drug concentration in each solvent and strong drug-solvent interaction due to perturbation in structural orientation of drug indifferent solvent has been observed.