Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2018 Vol: 10 Issue: 3

Solubility Enhancement by Solid Dispersion and Effervescence Assisted Fusion Technique Using Cilnidipine as a Model Drug

Abstract

The Poor Solubility of Drugs is a major problem which limits the development of highly potent pharmaceutics. Solubility Enhancement is one of the important parameters which should be considered for those drugs having poor aqueous solubility. Drugs belonging to Biopharmaceutical Classification System (BCS) class II are characterized by low aqueous solubility and high physiological permeability. Solid Dispersion Technique (SDM) and Effervescence Assisted Solid Dispersion Techniques (EASDT) using Modified Fusion Method are the process to enhance the solubility of poorly water soluble drugs. In this work, BCS class-II drugs Cilnidipine is used as a model drugs, having poor solubility but high permeability is individually incorporated with Mannitol, Citric acid, and Sodium bicarbonate (Hydrophilic Carriers used as Excipients) in different ratio respectively. SDMs of Cilnidipine were prepared by melting (Fusion) method using Mannitol. Scanning electron micrographs of EASDs showed better uniform distribution of drug particles in the carrier matrix. The present technique is better suitable for drugs having a low melting point or melt without charring.