Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 3

Solid supports in the synthesis of few vinyl quinolones

Abstract

The present investigation involves use of microwave technology aided by solid supports-alumina, montmorillonite clay, bentonite, silica gel , dowex and amberlite for the synthesis of few 4- substituted-3-vinyl quinolines and 4-substituted-3- vinyl quinoline-2(1H)-thiones, The results of the microwave reactions aided by solid supports ind icate significant increase in the yield of product and reduction in the time of synthesis comp ared to classic conditions and in microwave reactions without solid supports. Neutral alumina a nd K10 clay were found to be more efficient in the synthesis of chloro -4- alkyl -3-vinyl quino lines and 4- alkyl -3-vinyl quinoline-2(1H)- thiones. The used solid-supports can be easily sepa rated from the reaction mixture and recycled.