Skin and soft-tissue infections (SSTIs) are the most frequent forms of the disease. S. aureus is capable of causing a wide range of infections including skin infections, abscesses, toxic shock and scalded skin syndrome. The current study was undertaken to know the Antibiotic resistance of S. aureus causing SSTIs, isolated from patients attending the OPD of our tertiary care hospital. Pus samples were collected from patients presenting with ailments like abscesses, carbuncles, osteomyelitis and skin infections at our hospital OPD from June 2012 to June 2014. S. aureus was identified by conventional techniques. Antimicrobial susceptibility testing of the isolates were be performed by Kirby Bauer disc diffusion method . The data were recorded and analyzed at the completion of the study as per recommendations of the CLSI. During the study period a total of 50 isolates of S. aureus were isolated from SSTI infections in patients visiting OPDs. Among these 31 were isolated from male patients .Majority of the isolates were from (74%) were deep abscesses, were isolated were from middle age group of 20- 50 years age. Anti-biograms of S. aureus isolates revealed high level of resistance to penicillin, pefloxacin amoxicillin/clavulanic acid. The most effective agent against S. aureus isolates were linezolid, piperacillin/tazobactam followed by tetracycline. The current study revealed that majority of the isolates were from were deep abscesses, Anti-biograms of S. aureus revealed high level of resistance to penicillin, pefloxacin amoxicillin/clavulanic acid . The most effective agent against S. aureus isolates were linezolid, piperacillin/tazobactam followed by tetracycline.