Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2016 Vol: 8 Issue: 12

SIO2.CAA: An Efficient Catalyst for One Pot Synthesis of 4,6-Diarylpyrimidine-2(1H)-Ones or Thiones


An efficient method for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones or thiones by using SiO2.CAA. The condensation of acetophenone , aldehydes and Urea or thiourea in the presence of silica supported catalyst was employed to synthesize a variety of pyrimidinones or thiones in excellent yields. The remarkable feature of this synthic pathway are simple workup, shorter reaction times, high yields.