Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 2

Simultaneous UV Spectrophotometric Methods for Estimation of Amlodipine Besilate and Olmesartan Medoxomil in Tablet Dosage Form

Abstract

Two methods for simultaneous estimation of Amlodipine besylate and Olmesartan medoxomil in combined tablet dosage form have been developed. The first UV spectrophotometric method was a determination using the simultaneous equation method at 239 nm and 255 nm. The second UV spectrophotometric method is the Q – analysis (absorption ratio) method, which involves the formation of absorbance equation at 245 nm (isobestic point) and at 255 nm the maximum absorption of olmesartan medoxomil. The linearity ranges for Amlodipine besylate and olmesartan medoxomil were 2.5 – 30 μg/ml and 4 – 32 μg/ml respectively. The accuracy of the methods was assessed by recovery studies was found to be 99.76±0.5861 and 100.39±0.4168 for simultaneous equation method and 99.91±0.4216 and 100.16±0.1446 for Q analysis (absorption ratio) method for Amlodipine besylate and olmesartan medoxomil respectively. These methods are simple, accurate and rapid; those require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories.