A simple accurate, and precise effective simultaneous equation spectrophotometric method has been developed for estimation of cefepime hydrochloride and sulbactam sodium in injection dosage form. The Beer lambert law followed at concentration range 24-52 μg/ml and 16-26 μg/ml of cefepime hydrochloride and sulbactam sodium. The proposed method was validated and applied for estimation of cefepime hydrochloride and sulbactam sodium in combined dosage form.