A simple, fast, precise, specific, accurate reversed phase high performance liquid chromatographic (HPLC) method was developed and validated for the simultaneous determination of Paracetamol (PC) and Mefenamic acid (MA) in tablets. The column used was Inertsil ODS 3V C18, 250 x 4.6mm, i.d. 5μm and a mobile phase composed of methanol: buffer (0.02MKH2PO4) (75:25), pH 7.1 adjusted with 0.1N NaOH. The flow time was set at 1.0mL/min. Analysis was performed using UV detection at 275nm.. The retention times of PC and MA were found to be 2.88 mins and 4.49 mins respectively. Linearity was established for PC and MA in the range of 36-180 μg/mL and 40-200 μg/mL, respectively. Repeatability and intermediate precision were acceptable (RSD<2%). The percentage recoveries of PC and MA were found to be in the range of 98.32% to 100.78% and 98.15% to 99.02% respectively. The proposed method was validated and successfully used for estimation of paracetamol and mefenamic acid in the pharmaceutical dosage form