Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2016 Vol: 8 Issue: 6

Simultaneous determination of ciprofloxacin hydrochloride and enrofloxacin at poly (furosemide) modified carbon paste electrode by cyclic voltammetry

Abstract

A poly (Furosemide) modified carbon paste electrode (PFMCPE) was used for sensitive voltammetric determination of ciprofloxacin hydrochloride (CIP) and Enrofloxacin (ENRO). The surface morphology of PFMCPE was characterized by SEM. The electrochemical response of CIP and ENRO were investigated by cyclic voltammetric (CV) and differential voltammetric techniques (DPV). The effect of pH, concentration and sweep rate has been studied. The modified electrode was used for the simultaneous determination of CIP and ENRO in the phosphate buffer solution of pH 7.2. The low detection limit (LOD) and low quantification limit (LOQ) of ENRO and CIP were detected. This modified electrode was successfully used for the simultaneous determination of CIP and ENRO by resolving the overlapped voltammetric peaks by using cyclic voltammetry. The modified electrode showed high sensitivity, detection limit, high reproducibility, easy preparation and regeneration of the electrode surface.