Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 6

Simultaneous determination of Amlodipine Besilate and Valsartan in pharmaceutical formulation using high performance liquid chromatography

Abstract

A simple, selective, sensitive, precise, simultaneo us high performance liquid chromatographic analysis of commercial tablets formulation containi ng amlodipine besilate and valsartan are reported. Good chromatographic separation was achie ved using a Zarbax ODS (4.6 cm x 250 mm, 5 μ m). Past Number: 880952-702. S.N. VSF 006092 0 and a mobile phase consisting of acetonitrile-phosphate buffer (50/50, v/v) at a flo w rate 1.0 mL/min. The ultraviolet detector was set a wavelength of 254 nm. amlodipine besilate and valsartan were eluted at 1.5 and 4.2 min, respectively. No extraneous materials were found to interfere. The recoveries of amlodipine besilate and valsartan in pharmaceutical preparatio n were all greater than 98% and their relative standard deviations were less than 2.0%.