HDL cholesterol (HDL-C) level is a major risk factor in the Coronary Heart Disease (CHD).Thus interventions are required to increase HDL cholesterol to prevent the risk of Coronary heart disease. “Low HDL cholesterol” or “Hypoalpha”syndrome is the most frequent lipoprotein abnormality in coronary patients .HDL cholesterol promotes fibrinolysis. An open labelled cross sectioned study was conducted in master health check up, Out Patient Department, Sree Balaji Medical College And Hospital, Chromepet, during August 2015 to October 2015.In my study serum HDL cholesterol levels were estimated in young healthy population. 64 out of the 100 patients from study population had high serum HDL cholesterol levels (mean 42.3; SD 5.80). Treatment modalities to increase HDL cholesterol level can be adopted to avoid adverse cardiovascular outcomes