Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 4

Selective Extraction of 7-aminodeacetoxycephalosporanic acid and Cephalexin antibiotics with Aliquat-336


The reactive extraction of 7-ADCA (aminodeacetoxycephalosporanic acid) and Cephalexin with Aliquat-336 (tricaprylmethyl ammonium chloride) dissolved in n-butyl acetate as solvent has been studied over a pH range of 5 to 8. The effect of such parameters as Aliquat-336 concentration, pH and 7-ADCA and Cephalexin concentrations on distribution coefficient in the reactive extraction system has been evaluated. It was found that distribution coefficient (Kd) increases with increases of the aqueous phase pH implying that the anionic forms of the dissociated 7-ADCA and cephalexin are amendable for reactive extraction. Furthermore inference of practical relevance that could be drawn from the present study is that 7-ADCA and cephalexin can be selectively extracted from an aqueous solution typical of that encountered in biosynthesis of 7-ADCA and cephelexin. Study on reextraction of 7-ADCA and cephalexin from the extracted phase was carried out using an aqueous solution of acetate was found to be pH dependent which also attribute to ionization behaviour of the beta-lactams. Such observation is considered important as re-extraction at an appropriate pH value is possible.