Aqueous, ethanol and chloroform extracts of some plants used Igala folkloric medicine of North- Central Nigeria for the treatment of typhoid fever were investigated for their antibacterial properties against Salmonella typhi. Screening for the antibacterial activity was carried out by using a modification of the agar well diffusion technique. The extracts that showed significant antibacterial activity were further investigated for their Minimum Inhibitory Concentrations [MIC]. The aqueous extract of D. oliveri and the ethanol extract of M. indica had MIC of ≤12.5mg/ml which was comparable to that of gentamycin and better than those of amoxicillin and chloramphenicol, 25mg/ml and 100mg/ml respectively. However, the aqueous extract of N. latifolia which had an MIC of 25mg/ml had the widest zone of inhibition of all the extracts investigated from 25mg/ml to 100mg/ml concentration of the extracts. Thus weight for weight, the aqueous extract of N. latifolia was the most potent at higher concentrations. The results obtained validate the use of A. occidentale, A. vogelii Planch, D. oliveri, M. indica and N. latifolia in Igala folkloric medicine for the treatment of typhoid fever.