Natural products are often a source for bioactive compounds which have great potential for developing novel therapeutic agents. In this study, two Libyan medicinal plants Helianthemum lippii (H. lippii) and Launaea residifolia (L. residifolia) were collected from El-Jabel El- Garbi (Gharian) in the Spring season (2010). They were extracted successively by using microwave technique with three different solvents of different polarities. The analgesic activity of these plant extracts was evaluated using the hot-plate method and the anti-inflammatory activity was evaluated using Carrageenen-induced paw edema method. The methanol and chloroform extracts exhibited significant analgesic activity at the doses tested while the petroleum ether extracts of both plants did not show any significant effect. In addition, the anti-inflammatory activities of various extracts showed a significant percentage inhibition of paw edema for H. lippii extracts in methanol and chloroform but not in petroleum ether. Moreover, the results exhibit different percentage inhibitions of paw edema for L. residifolia extracts in methanol, chloroform and petroleum ether. The analgesic and anti-inflammatory effects produced by the extracts may be attributed individually or collectively to the flavonoids and tannins. H. lippii and L. residifolia can be introduced as new plant sources for analgesics and anti inflammatory agents. The methanolic and chloroform extracts of both plants showed a significant analgesic activity due to an increase in the reaction time (p<0.05) in comparison to controls, where codeine was used as standard analgesic drug. The petroleum ether extracts did not show any activity as analgesic. The anti-inflammatory activity was also evaluated using the Carrageenan-induced paw edema method, the methanolic extract of H. lippii (53.42%) exhibit activity comparable to that of aspirin standard antiinflammatory drug (62.28%) with no significant difference, while the petroleum ether extract of L. residifolia (31.65%) exhibited a moderate anti-inflammatory activity (p<0.01) in comparison with aspirin as a standard. The chloroform extract of H. lippii, the methanol and chloroform extracts of L. residifolia exhibited a weak inhibitory effect on paw edema volume with percentage inhibition of (23.60%, p<0.05), (16.45%, p>0.05) and (14.56%, p>0.05) respectively compared to control.