Among the diazole derivatives, thiazoles, imidazoles and pyrazoles are common scaffolds in highly significant biomolecules. These moieties and their derivatives have long been used as precursors for the synthesis of biologically active molecules since they possess wide spectrum of activity. This review highlights vast number of potential structures and potential therapeutic uses of only on those moieties containing five-membered heterocyclic such as imidazoles, thiazoles and Pyrazoles and their substitutes.