During pregnancy various drugs are associated with contraindication, hence their application is limited and dangerous to mother along with fetus. Even though during pregnancy medication is less preferred but in certain cases cannot be escaped to treat the ailments in mother. So herein we discussed the medication that can be used safely during pregnancy along with the drugs which are unsafe or highly contraindicated for both mother and the fetus. The problems or complications may be attributed by possible drug interactions during the pregnancy. We tried to cover all related drugs which are safe or unsafe with their chemical structures and major associated problems. The purpose of this review is to create a list of safe medications which can be taken during pregnancy with unsafe and highly contraindicated drugs as a quick reference for health care professionals.