Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 1

Ring deactivating effect on antimicrobial activities of metal complexes of the schiff base of p-nitroaniline and isatin

Abstract

The Schiff base of “p”-nitroaniline and isatin was prepared by refluxing method [1]. Cobalt (II) and Nickel (II) metal complexes of this ligand were also synthesized. These compounds were analyzed using spectroscopic means, which were 1HNMR, 13C NMR IR and UV spectra. The ligand and the complexes were screened for in vitro antibacterial activity using Mueller-Hinton agar and antifungal activity using Sabouraud dextrose agar media. The antibacterial activity was evaluated against three Gram-positive bacteria (Staphylococcus aureus, Micrococcus luteus and Bacillus subtilis) and three Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli and Salmonella typhi). The antifungal activities of the compounds were evaluated against three fungi (Aspergillus niger, Aspergillus flavus and Candida albicans). The Cobalt(II) complex showed activity against Bacillus subtilis and Escherichia coli, with the minimum inhibitory concentration (MIC) value of 5.0 μg/ml. The ligand and the Nickel(II) metal complex showed no activity against all tested bacterial. Also no antifungal activity was displayed by all compounds and this must have been due to the deactivation of the ring system by the electron withdrawing nitro group at the para position of aniline.