In this paper, the three major indexes of production factor, agglomeration state and national policy influencing the difference were extracted on the basis of the research on China’s regional difference in culture industry and the empirical analysis was made according to the Theil Index and analysis model of spatial autocorrelation index and numerical theory of spatial econometric model by use of the national standard statistical data concerning culture industry of 2008 and 2012, to obtain the tendency of high development level in the eastern China and low development level in western China concerning Chinese cultural industry development and the relevant analysis results related to local cultural industry level and the cultural level in adjacent area and provide the theoretical basis for analysis of China’s regional difference in culture industry.