For heterogeneous fractured reservoir, the production capacity of hydraulic fracturing well is limited by the ability of hydraulic fracture communication with natural fracture. This paper uses the numerical analysis method, according to the fluid-structure interaction theory and fracture mechanics theory, the three-dimensional fluid-structure coupling hydraulic fracture mechanics model is established based on the principle of hydraulic fracturing, using the fluid-structure coupling element C3D8RP to simulation the behavior of seepage and stress coupling on the reservoir rock, the fracture damage element with pore pressure is used to simulate the fracture propagation. The numerical analysis indicated that the main factors influencing the shear slippage damage of natural fracture is approaching angle and differential horizontal stress. While in the condition of low differential horizontal stress and approaching angle, under the action of hydraulic fracture, the shear strain is smaller when hydraulic fracture extension through the interface layer, and the energy dissipation is less, the hydraulic fracture is easily through the interface layer and penetration with the natural fracture, thus result in the open of the natural fracture and the dense hydraulic fracture network is formed.