With nonlinearity, large lag and time-varying model parameters of cement rotary kiln, this paper proposed a burning zone temperature control system of cement rotary kiln based on CMAC neural network. By Dynamic adjustment of PID controller parameters with CMAC neural network, combined with rotary kiln temperature control mechanism, the temperature controller based on CMAC-PID was designed. Then the good dynamic and static characteristics and anti-interference ability of system were verified by simulation test. Finally hardware and software design of temperature control system were completed. In order to improve the rapidity of PID parameters online adjustment, OB35 program block in PLC was used to real-time adjustment of CMAC parameters. This control system has been applied to QuFu cement rotary kiln project, realizing none overshoot and high control precision of the burning zone temperature.