The aim of this study is to make a probably clear analysis of the new English teaching mode based on Informatization at college nowadays. With the development of modern science and technology, especially the computer and internet technology, Informatization has a greater and greater impact on the daily life in recent decades, and in education the whole atmosphere is influenced a lot more than in other areas. English teaching and learning mode faces profound challenge and is definitely going to change under such environment. To catch up with the trend of the times and make itself more efficient, the college English teaching and learning mode needs to transform its style to adapt itself to the rapidly-changing society. This paper uses relevant data analysis from several investigations and build a comparison analyzing model to make clear what the new teaching and learning mode will be with Informatization and how the Informatization affect the college English teaching, involving the teachers’ performance and the students’ reaction presented in the investigation results.