Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2015 Vol: 7 Issue: 6

Regioselective synthesis of N-formohydrazide and formyl pyrazole analogs as potent antimicrobial agents


A series of new (E)-N-(aryl)-N'-(1-(thiophen-2-yl)ethylidene)formohydrazides 2(a-g) and 1-(aryl)-3-(thiophen-2-yl)- 1H-pyrazole-4-carbaldehyde, 3(a-g) were prepared by the controlled Vilsmeier-Haack reaction. The reaction of (E)-1-aryl-2-[(1-thiophen-2-yl)ethylidene]hydrazines 1(a-g) with Vilsmeier-Haack reagent under different reaction conditions afforded the compounds 2(a-g) and 3(a-g) in good yield. The synthesized compounds were characterized by IR, 1H NMR, 13C NMR, Mass spectral, x-ray diffraction studies and elemental analysis. The compounds were screened for their antimicrobial susceptibility against different bacterium and fungi species.