Original Articles: 2011 Vol: 3 Issue: 2
Regioselective formylation and chemoselective oxidation of 1, 3, 5-triaryl pyrazoline: Synthesis of 4-(3,5-diaryl-1H-pyrazol-1-yl) benzaldehydes
Abstract
A novel regioselective formylation of 1, 3, 5-triarylpyrazoline by using Vilsmeire- Haack
reaction is described. The formylation only observed in N-phenyl ring in the presence of
phenolic or methoxy group in 3 & 5-aryl ring. Iodine, a readily available reagent, was found to
be effective in carrying out chemoselective oxidation of 1, 3, 5-triaryl pyrazolines to 1, 3, 5-
triaryl pyrazoles.