Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 3

Reactivity of substituted Pyrimidines with Some Nucleophiles


A series of five 3-methyl-1-phenyl-4-substituted pyrazolo[3,4-d]pyrimidin-6-ones(Ia-e) and five 3- methyl-1-phenyl-4-substituted pyrazolo [3,4-d]pyrimidin-6-thiones (IIa-e) were prepared and some of them were subjected to aminolysis as well as hydrazinolysis. The reaction of the 6- chloro derivatives (IV) with amino acids to give pyrazolo pyrimidine derivatives (IX) was investigated. A few of the pyrimidin-6-thiones were cyanoethylated under drastic conditions to give (XI), and some of them were also hydroxyethylated (IX).

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