This paper describes the analytical method suitable for validation of Piroxicam by reversed Phase High Performance liquid chromatography (RP-HPLC) method. The method utilized RPHPLC (Younglin with UV-detector) model and a column, 150mm ´ 4.6 mm, 5m (Symmetry, ODS- 3V, 150mm ´ 4.6mm, 5m). The mobile phases were comprised of Methanol and Water pH 3.2 (55:45v/v). Validation experiments were performed to demonstrate System suitability, precision, linearity and Range, Accuracy study, stability of analytical solution and robustness. The method was linear over the concentration range of 1-200 mg/ML-1. The method showed good recoveries (99.8 – 102.9%).